Table 1 Effects of orally administered bisphenol A (BPA), Isosorbide (ISO) and cyclohexanedimethanol (CHDM) and subcutaneously administered testosterone propionate (TP) on body and androgen-sensitive organ weights of castrated rats
Treatmenta | Body weight(g) | LABC(mg) | Penis(mg) | Cowper’s glands(mg) | S.V.(mg) | Prostate(mg) |
INT | 267.9±12.5 | 646.1±22.8 | 262.2±12.3 | 36.0±1.8 | 226.3±11.8 | 130.7±5.6 |
ORX | 275.8±7.4 | 230.2±21.4 | 151.0±10.6 | 4.6±0.5 | 28.5±2.4 | 12.6±1.2 |
ORX+TP | 307.3±7.3 | 553.2±17.5 | 227.5±7.7 | 19.0±0.8 | 141.2±7.7 | 75.0±4.9 |
BPA-40 | 240.0±5.1** | 161.0±7.7* | 117.3±4.4* | 3.3±0.2* | 22.8±1.3* | 8.1±0.5** |
BPA-40+TP | 255.3±8.3†† | 459.4±13.4†† | 207.4±4.1† | 19.1±1.1 | 140.9±4.1 | 69.0±4.0 |
BPA-400 | 254.7±6.6 | 209.1±9.7 | 132.5±5.1 | 3.7±0.4 | 27.5±1.2 | 11.3±0.5 |
BPA-400+TP | 273.1±5.9†† | 463.3±13.5†† | 514.8±7.7 | 15.1±0.8†† | 131.3±5.2 | 71.6±2.7 |
ISO-40 | 266.3±4.0 | 251.6±14.0 | 151.1±3.6 | 5.9±0.7 | 31.1±2.8 | 10.2±0.8 |
ISO-40+TP | 284.8±7.9 | 485.5±21.6† | 212.1±3.1 | 17.5±1.1 | 127.7±12.2 | 51.0±1.9††† |
ISO-400 | 281.5±9.0 | 238.6±11.3 | 151.0±6.1 | 5.6±0.3 | 25.3±2.1 | 11.2±0.8 |
ISO-400+TP | 285.6±7.2 | 491.7±3.8†† | 224.2±6.6 | 19.2±0.5 | 142.0±5.4 | 70.9±1.7 |
CHDM-40 | 254.8±5.1* | 165.9±19.2* | 124.4±4.7* | 3.7±0.3 | 19.7±1.2** | 8.1±0.3** |
CHDM-40+TP | 293.7±6.4 | 450.7±16.2†† | 219.5±6.0 | 13.1±1.0††† | 112.8±3.5†† | 56.5±3.6†† |
CHDM-400 | 274.6±8.3 | 170.3±14.3* | 122.1±4.2* | 3.5±0.2* | 17.4±1.0*** | 9.2±0.7* |
CHDM-400+TP | 290.9±6.6 | 398.6±21.5††† | 187.8±8.9†† | 10.8±0.9††† | 82.5±5.3††† | 36.5±3.7††† |
a Castrated immature rats were administered with TP by subcutaneous injection for 10 days. One day after the final treatment, the accessory sex organs were removed carefully and weighed separately.
Symbols *, ** and *** meant significant difference in comparison between ORX group and test material group. *, P<0.05; **, P<0.01; ***, P<0.001.
Symbols +, ++ and +++ meant significant difference in comparison between ORX group and test material group. †, P<0.05; ††, P<0.01; †††, P<0.001.