Table 2 Effects of orally administered di-2-ethylhexyl phthalate (DEHP), 2-ethylhexyl oleate (IOO), 2-ethylhexyl stearate (IOS) and acetyl triethyl citrate (ATEC) and subcutaneously administered testosterone propionate (TP) on body and androgen-sensitive organ weights of castrated rats
Treatmenta | BodyWeight (g) | LABC(mg) | Penis(mg) | Cowper’sglands (mg) | S.V.(mg) | Ventral prostate(mg) |
INT | 301.6±7.6 | 736.7±29.4 | 271.3±12.5 | 26.2±2.3 | 193.4±9.7 | 146.0±9.8 |
ORX | 281.3±7.7 | 301.4±52.3 | 158.3±11.1 | 5.4±0.9 | 28.0±3.8 | 29.3±9.9 |
ORX+TP | 313.2±6.3 | 671.5±49.0 | 266.2±12.8 | 18.2±0.8 | 170.3±12.5 | 91.5±9.7 |
DEHP-40 | 276.2±6.1* | 193.7±17.1 | 98.3±2.4*** | 2.3±0.2*** | 22.4±1.3 | 8.5±0.5* |
DEHP-40+TP | 310.3±5.2 | 548.8±27.5 | 192.5±17.1†† | 16.6±1.1 | 163.9±8.0 | 75.6±4.1 |
DEHP-400 | 302.8±8.7 | 245.1±10.5 | 153.4±7.5 | 5.9±1.2 | 28.5±4.0 | 21.3±4.7 |
DEHP-400+TP | 305.2±15.9 | 619.1±22.0 | 255.5±19.3 | 17.8±2.5 | 165.5±15.4 | 86.2±5.5 |
IOO-40 | 252.3±7.1* | 153.6±6.2z* | 112.8±3.0** | 2.6±0.2** | 16.8±0.9** | 7.8±0.5* |
IOO-40+TP | 250.8±4.7††† | 520.8±16.7† | 218.6±2.9†† | 17.7±0.9 | 172.3±10.4 | 79.9±3.0 |
IOO-400 | 216.6±17.9** | 143.8±12.2* | 111.3±3.2** | 3.2±0.3* | 17.7±1.0* | 7.0±0.4 |
IOO-400+TP | 244.2±6.6††† | 489.8±18.4† | 199.2±7.3†† | 20.3±1.4 | 137.2±9.5 | 61.5±6.2† |
IOS-40 | 265.0±8.7 | 163.3±9.8* | 116.9±5.0* | 2.8±0.2** | 20.4±1.6 | 8.4±0.7 |
IOS-40+TP | 281.8±7.0†† | 451.7±12.9† | 217.4±12.2† | 18.1±0.9 | 121.6±5.3†† | 58.5±2.9*†† |
IOS-400 | 274.4±11.5 | 210.8±18.9 | 138.9±8.5** | 4.7±0.7* | 25.3±1.3*** | 12.4±1.7 |
IOS-400+TP | 286.3±3.1†† | 460.0±22.8†† | 206.1±6.0†† | 17.7±1.8 | 138.3±6.9† | 63.9±2.3† |
ATEC-40 | 287.5±5.7 | 209.3±10.1 | 123.0±4.5* | 3.8±0.4 | 26.0±1.4 | 11.5±0.9 |
ATEC-40+TP | 313.9±10.8 | 539.2±21.2† | 218.8±10.1† | 17.1±0.8 | 159.6±9.2 | 80.4±2.2 |
ATEC-400 | 287.9±9.1 | 192.4±6.9* | 114.6±7.0** | 2.2±0.2*** | 22.7±1.8 | 10.9±1.2 |
ATEC-400+TP | 309.0±3.2 | 529.3±24.7† | 209.7±13.0† | 18.3±1.3† | 154.3±10.9 | 78.2±3.1 |
a Immature castrated rats were administered with TP by subcutaneous injection for 10 days. One day after the final treatment, the accessory sex organs were removed carefully and weighed separately.
Symbols *, ** and *** meant significant different in comparison between ORX group and test material group. *p<0.05; **p<0.01; ***p<0.001.
Symbols †, †† and ††† meant significant different in comparison between ORX+TP group and test material group. †p<0.05; ††p<0.01; †††p<0.001.
INT, intact; LABC, levator ani-bulbocavernosus; S.V. seminal vesicle; ORX, orchidectomy.